What is OvaStem®

OvaStem® is a patented stem cell procedure for the treatment of Premature Ovarian Insufficiency (POI)/Failure (POF) offered by Creative Medical Technology Holdings, Inc. The OvaStem® procedure is performed using FDA-approved equipment by a licensed physician, that uses intra-ovarian injection of autologous bone marrow aspirate in the treatment of POI/POF. The ultimate goal of the OvaStem® procedure is a successful, full-term pregnancy without the requirement of a donor egg.

How OvaStem® Works

  • Immunodulatory Effect: balancing pro-inflammatory and anti-inflammatory cytokines, in addition to regulating oxidative stress
  • Antifibrotic Effect: inhibition of fibroblasts and extracellular matrix deposition within the ovary
  • Folliculogenesis: promotion of cell proliferation allowing for follicular growth within the ovary
  • Angiogenesis: aids with angiogenesis and vasculogenesis within the ovary

About Premature Ovarian Insufficiency/Failure

  • Premature ovarian failure or insufficiency (POF or POI) is characterized by the presence of amenorrhea for more than 4months in women under 40 years of age with an elevated serum level of FSH
  • 1 in 4 (26%) women in this group have difficulty getting pregnant or carrying a pregnancy to term
  • In the United States, among heterosexual women aged 15 to 49 years with no prior births, about 1 in 5 (19%) are unable to get pregnant after one year of trying
  • The average pregnancy rate in women with premature ovarian insufficiency (POI) was <1:9200, indicating that infertility is one of the most concerning problems of patients with POI.
  • The prevalence of POI has risen from 1% to nearly 2% in the last few decades


Premature Ovarian Insufficiency/Failure is a major healthcare crisis. OvaStem® is a non-surgical approach targeting the root cause of this debilitating disease.

• Rejuvenates ovarian tissues

• Improves modulation of reproductive hormones

• Slows the rate of premature ovarian aging

• Allows for maturation of natural follicles (eggs)

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